Fri Apr 15 2022

21 articles - From Saturday Apr 09 2022 to Friday Apr 15 2022

parm_toc.knit

Guidelines

Guidelines, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews


Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Kidney Dis

Association Between Acute Kidney Injury and Dementia in the Atherosclerosis Risk in Communities (ARIC) Study.

Participants who experienced a hospitalization for AKI were at increased risk of dementia.

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Black and White Adults With CKD Hospitalized With Acute Kidney Injury: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study.

In this multi-center prospective cohort of CKD patients, racial disparities in AKI incidence were modest and were explained by differences in pre-hospitalization clinical risk factors. Index words Acute kidney injury (AKI), chronic kidney disease, racial disparities, CRIC, clinical risk factors.

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Cancer Risk and Mortality in Patients With Kidney Disease: A Population-Based Cohort Study.

Cancer incidence in the setting of kidney disease is substantial. Cancer risk was increased in mild-to-moderate CKD and among transplant recipients, but not in advanced kidney disease. Cancer-related mortality was significantly higher among patients with kidney disease, particularly urologic cancers and myeloma. Strategies to detect and manage these cancers in the CKD population are needed.

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J Am Soc Nephrol

High-Resolution Mass Spectrometry for the Measurement of PTH and PTH Fragments: Insights into PTH Physiology and Bioactivity.

Traditional second-generation PTH immunoassays collectively measure PTH 1-84, PTH fragments, and post-translationally modified PTH 1-84, making it difficult to accurately predict the character of underlying renal osteodystrophy. This review highlights current advances in methods available for PTH measurement and the clinical relevance of PTH fragments in CKD. We emphasize the usefulness of mass spectrometry as a potential reference method for PTH measurement.

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Kidney Int

Calculated versus measured albumin-creatinine ratio to predict kidney failure and death in people with chronic kidney disease.

Models including measured or calculated ACR had similar discrimination: year one-to-five area under the receiver operating characteristic curve of 83-89% for kidney failure and 69-75% for mortality. Thus, if confirmed in different ethnic groups, calculated ACR can be used for risk predictions when the measured ACR is not available. PCR-calculated ACR may have superior performance than dipstick-calculated ACR.

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Harmonization of epidemiology of acute kidney injury and acute kidney disease produces comparable findings across four geographic populations.

Standardised 1-year mortality was lower (21.0-25.5% across cohorts) among patients with AKI/AKD ascertained using a baseline creatinine >90 days prior. These findings illustrate that the incidence and prognosis of AKI and AKD based on KDIGO criteria are consistent across 3 high-income countries when capture of laboratory tests is complete, creatinine-based definitions are implemented consistently within but not beyond a 90-day period, and adjustment is made for population age and sex. These approaches should be consistently applied to improve the generalizability and comparability of AKI research and clinical reporting.

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Nephrol Dial Transplant

De novo major cardiovascular events in kidney transplant recipients: a comparative matched cohort study.

De novo MACE in KTRs was much lower than dialysis patients and even similar risk to the GP, while once it occurred it affected elevated mortality risk in KTRs.

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Recurrence of immune complex and complement-mediated membranoproliferative glomerulonephritis in kidney transplantation.

One-fourth of patients with native kidney disease due to MPGN developed clinical recurrence in the allograft, especially in cases with complement-mediated disease or in those associated with dysproteinemia. The kidney outcomes of disease recurrence with currently available therapies are heterogeneous and thus, more effective and individualized therapies are needed.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

J Am Soc Nephrol

A View on Cathepsin C as a Target for Therapy in AAV.

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Further Evidence for the Mucosal Origin of Pathogenic IgA in IgA Nephropathy.

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Kidney Int

TCRaß+ CD4-/CD8- "double negative" T cells in health and disease - implications for the kidney.

However, little is known about these cells in other kidney diseases. Therefore, it is important to better understand different functions of DN T cells and their signaling pathways as promising therapeutic targets, particularly with the increasing application of T cell directed therapy in humans. In this review, we aim to summarize studies conducted on DN T cells in normal and diseased organs in the setting of different disease models with a focus on kidney.

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Nat Rev Nephrol

COVID-19 and kidney disease: insights from epidemiology to inform clinical practice.

Study findings also require attentive appraisal in terms of the effects of confounding, collider bias and chance. As this pandemic continues and in the future, the implementation of sustainable and integrated research infrastructure is needed in settings across the world to minimize infection transmission and both prevent and plan for the short-term and long-term complications of infectious diseases. Registries can support the real-world evaluation of vaccines and therapies in patients with advanced kidney disease while enabling monitoring of rare complications.

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Drosophila melanogaster: a simple genetic model of kidney structure, function and disease.

melanogaster orthologues that are enriched and functionally relevant in fly renal tissues. This similarity has allowed investigations of epithelial transport, kidney stone formation and podocyte and proximal tubule function. Furthermore, a range of unique quantitative phenotypes are available to measure function in both wild type and disease-modelling flies.

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Letters&Replies

Letters to the editors and authors’ replies

J Am Soc Nephrol

Authors' Reply: Predicting Kidney Response to Plasma Exchange in ANCA-Associated Vasculitis: Need for Plausible Models.

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Predicting Kidney Response to Plasma Exchange in ANCA-Associated Vasculitis: Need for Plausible Models.

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Unveiling the Role of Additional Histological Parameters in ANCA-Associated Vasculitis.

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Kidney Int

Early treatment with sotrovimab monoclonal antibody in kidney transplant recipients with Omicron infection.

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Humoral response after a fourth "booster" dose of a Covid-19 vaccine following a 3-dose regimen of mRNA-based vaccination in dialysis patients.

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Others

all remaining publications eg case reports, images of the month, etc…

Clin J Am Soc Nephrol

The Role of Glucagon-Like Peptide 1 (GLP-1) Receptor Agonists in the Prevention and Treatment of Diabetic Kidney Disease: Insights from the AMPLITUDE-O Trial.

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Nat Rev Nephrol

COVID-19 vaccine hesitancy.

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Supporting sexual and gender minority health-care workers.

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